Most of the Fate games have been sci fi due to circumstance that the other games my table plays are fantasy so FATE gets used as a “change of pace” rpg. I’ve run a Venture City campaign, which as time went on I started pulling ideas from a lot of comics I’ve read as well as sci fi thriller novels and the like.
I also ran a modified Mindjammer campaign after that, and I pulled a lot of inspiration from actual astrophysics and scientific concepts. Reading through what some scientists speculate about dark matter, the fermi paradox, etc, was really interesting. I also liberally pulled from popular sci fi tropes. Ironically, when I had written the setting/framework, I was originally imagining a Mass Effect style tone, but when my players took the wheel, it ended up more in something like Farscape territory (which is still great, mind you, and I rolled with it accordingly).